Keywords
ovarian reserve
in vitro fertilization
How to Cite
Abstract
Study question: Is it possible to improve ovarian reserve parameters and oocyte retrieval in low responders who undergo intraovarian injection of platelet-rich plasma (PRP)? Summary answer: intraovarian PRP injection improved ovarian reserve parameters in low responders within 3 months, without increasing the number of oocytes retrieved. What is already known: it is postulated that PRP could be beneficial in delaying follicle atresia and oocyte degeneration, as well as promoting the development of primordial and primary follicles up to the pre-antral stage. Study design: prospective cohort study. Materials and methods: we included 61 low responder women who underwent PRP injection between October 2021 to March 2022 in our institution, comparing pre and post PRP ovarian function. In addition, we studied IVF outcomes of a subgroup of patients after the intervention with respect to the latest previous one. Results: an improvement in ovarian reserve was observed in relation to previous values: FSH (14.25 vs. 10.28, p=0.04), AMH (0.43 vs. 0.54, p=0.11), antral follicle count (3.86 vs. 5.57, p=0.001); as well as a higher number of evolved embryos (0.65 vs. 1.4, p=0.01); with no impact on the number of oocytes retrieved or the number of embryos produced. Limitations: the main limitation of this study is the small sample size, the short follow-up period, and the fact that it does not evaluate pregnancy outcomes after embryo transfers. Implications: although experimental, intraovarian PRP could restore ovarian function and be postulated as an alternative to oocyte donation in patients with low ovarian reserve who do not accept this treatment. There is a lack of randomized controlled trials to support these findings.
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